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Enzymes

A mindful characterization of enzymes always requires a sequence of complex analytical assays in order to ensure the structural and functional integrity of the biomolecule.

Biofidus offers a holistic and state-of-the-art analytical service platform for an in-depth analysis of the protein primary structure, amino acid modifications, purity, concentration, as well as functionality in cell-based assays. We are specialists in determining protein glycosylation structures, which are among the most important protein modifications having significant influence on function and stability of biopharmaceutical molecules.

Our vast experience and deep knowledge in this field allows us to guide you through the variety of available methods and help you find the optimal analytical solution for your project. In accordance with your needs, we adapt and, if required, qualify (according to ICH guidelines) our platform methods tailored to your drug substance (DS), its individual formulation matrix and your distinct analytical question.

Get in contact with us to quickly find the optimal setup for your analytical challenge and to speak directly from expert to expert

Our capabilities

Standalone and integral bioanalytical services

draft of chemical sctructure of a fictive carbon hydrate backbone

PROTEIN SEQUENCE ANALYSIS

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IMPURITY ANALYSIS
draft of chemical sctructure of a fictive carbon hydrate backbone with two phenyl groups
AMINO ACID (AA) MODIFICATIONS
draft of two aggregated igG antibodies generated by Biofidus AG
AGGREGATION ANALYSIS
draft of two igG antibodies one with a circled plus and one with a circled minus to symbolise charge heterogeneities generated by Biofidus AG
CHARGE HETEROGENITY
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BIOACTIVITY STUDIES
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HIGHER ORDER STRUCTURE CHARACTERIZATION
draft of igG Antibody with glycosylation pattern at the FC region generated by Biofidus AG
GLYCOSYLATION ANALYSIS
draft of two test tubes connected via a tube to symbolise CE analysis generated by BIofidus
CE ANALYSIS
draft of test tubes in a rack generated by Biofidus AG
CELL BASED ASSAYS
draft of typical SPR binding curves in an xy diagram generated by Biofidus AG
SPR ANALYSIS

Tell us about your project

We‘ll advice you to define your assay needs

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Technologies used

Our Expert Tobias Luttermann advices you on for all analytical requests related to enzymes.

Phone: +49(0)521 89 739 064
Mail: Tobias.Luttermann@Biofidus.de

Tobias Luttermann Director Genome & Vector Characterization Biofidus AG
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