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Antibody Drug Conjugates

Antibody-Drug Conjugates (ADC) are one of the most promising and fastest growing therapeutical approaches to treat specific cancer types. Due to their special peculiarity, they should only target and kill tumor cells without effecting healthy cells. To ensure this specific and highly targeted binding to degenerated cells, a precise knowledge of the structure and binding properties of the antibody component is of utmost importance.

Our bioanalytical service includes a broad range of state-of-the-art bioanalytical services to identify the structural as well as the functional characterization of ADCs allowing us to provide you with a suitable analytical package for your analytical challenge.

Besides an in-depth analysis of the protein primary structure, post translational modifications, the drug-antibody ratio (DAR) and the level of aggregation, we are experts in analyzing the functional properties of your lead molecules via customized cell-based assays and surface plasmon resonance (SPR) analysis.

Our vast experience and deep knowledge in this field allows us to guide you through the variety of available methods and help you find the optimal analytical solution for your project.

In accordance with your needs, we adapt and, if required, qualify (according to ICH guidelines) our platform methods tailored to your drug substance (DS), its individual formulation matrix and your distinct analytical question.

Get in contact with us to quickly find the optimal setup for your analytical challenge and to speak directly from expert to expert.

Our capabilities

Standalone and integral bioanalytical services

Protein Sequence Analysis

PROTEIN SEQUENCE ANALYSIS

Impurity Analysis
IMPURITY ANALYSIS
Amino Acid Modifications
AMINO ACID (AA) MODIFICATIONS
Aggregation Analysis
AGGREGATION ANALYSIS
Charge Heterogenity
CHARGE HETEROGENITY
Bioactivity
BIOACTIVITY STUDIES
Higher Order Structure
HIGHER ORDER STRUCTURE CHARACTERIZATION
lycosylation Analysis
GLYCOSYLATION ANALYSIS
CE Analysis
CE ANALYSIS
Cellbased Assay
CELL BASED ASSAYS
SPR Analysis
SPR ANALYSIS

Tell us about your project

We‘ll advice you to define your assay needs

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Technologies used

Our CEO Dr. Benjamin Müller advices you on all your requests concerning the general topic of protein characterization.

Phone: +49(0)521 89 739 060
Mail: Benjamin.Mueller@Biofidus.com

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