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Nanobodies

In the recent years, the interest and application of nanobodies or single-domain antibodies has grown significantly. Their unique chemical properties have made them promising candidates for a whole new kind of delivery systems and therapeutic methods.

Biofidus provides a broad range of state-of-the-art analytical techniques to support your biologics. We cover the structural as well as the functional characterization of proteins allowing us to provide you with a complete analytical package for your analytical challenge.

Besides an in-depth analysis of the protein primary structure, amino acid modifications, charge and size heterogeneity, we are experts in analyzing the functional properties of your lead molecules via customized cell-based assays and surface plasmon resonance (SPR) analysis.

Our vast experience and deep knowledge in this field allows us to guide you through the variety of available methods and help you find the optimal analytical solution for your project.

In accordance with your needs, we adapt and, if required, qualify (according to ICH guidelines) our platform methods tailored to your drug substance (DS), its individual formulation matrix and your distinct analytical question.

Get in contact with us to quickly find the optimal setup for your analytical challenge and to speak directly from expert to expert.

Our capabilities

Standalone and integral bioanalytical services

draft of chemical sctructure of a fictive carbon hydrate backbone

PROTEIN SEQUENCE ANALYSIS

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IMPURITY ANALYSIS
draft of chemical sctructure of a fictive carbon hydrate backbone with two phenyl groups
AMINO ACID (AA) MODIFICATIONS
draft of two aggregated igG antibodies generated by Biofidus AG
AGGREGATION ANALYSIS
draft of two igG antibodies one with a circled plus and one with a circled minus to symbolise charge heterogeneities generated by Biofidus AG
CHARGE HETEROGENITY
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BIOACTIVITY STUDIES
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HIGHER ORDER STRUCTURE CHARACTERIZATION
draft of igG Antibody with glycosylation pattern at the FC region generated by Biofidus AG
GLYCOSYLATION ANALYSIS
draft of two test tubes connected via a tube to symbolise CE analysis generated by BIofidus
CE ANALYSIS
draft of test tubes in a rack generated by Biofidus AG
CELL BASED ASSAYS
draft of typical SPR binding curves in an xy diagram generated by Biofidus AG
SPR ANALYSIS

Tell us about your project

We‘ll advice you to define your assay needs

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Technologies used

Our CEO Dr. Benjamin Müller advices you on all your requests concerning the general topic of protein characterization.

Phone: +49(0)521 89 739 060
Mail: Benjamin.Mueller@Biofidus.com

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